BlogWhat is the endocannabinoid system?

What is the endocannabinoid system?

3 min read

Sam North

what is the endocannabinoid system

Here, we aim to take new patients through all the basics and get them ready to make informed decisions about their cannabis-based therapy. This is not a substitute for a consultation with a prescribing specialist, but it may help you understand the concepts better.

And what better place to continue the series than with the endocannabinoid system - a crucial biological system that regulates homeostasis and one with which cannabis compounds can interact.

Contents

What is the endocannabinoid system made up of?

There are three main pieces to the ECS puzzle:

  • Endocannabinoids - internally produced cannabinoids that bind to and activate the ECS receptors
  • Receptors - CB1 and CB2, these specialised proteins receive messages and transmit them to the cell
  • Metabolic enzymes - responsible for breaking down endocannabinoids after interacting with the receptors.

How does cannabis interact with the ECS?

Well, you might have noticed that "cannabinoid" makes up a significant portion of the term "endocannabinoid system." This biological system is named after the cannabinoids that interact with it - both the internal cannabinoids (endocannabinoids) and external ones (phytocannabinoids).

THC and CBD are phytocannabinoids - both can influence the ECS and modulate its responses.

THC binds to the CB1 receptors directly. CB1 receptors are mostly located in the central nervous system, and their activation can lead to the psychoactive effects commonly associated with recreational marijuana use. This type of activation can also have a range of therapeutic effects, helping to alleviate symptoms such as pain, nausea, and muscle spasms.

CBD on the other hand, has a more indirect interaction with the ECS. It can enhance the activity of internal cannabinoids and block the breakdown of endocannabinoids by metabolic enzymes. This can have a balancing effect on the ECS and potentially alleviate symptoms associated with conditions like anxiety, pain, and inflammation.

For a more thorough breakdown of the endocannabinoid system, check out this article.

Why does this matter to medical cannabis patients?

Understanding the endocannabinoid system is crucial because it helps us understand how and why cannabis-based medicines can offer such diverse therapeutic effects. By targeting specific receptor sites, cannabis compounds can address imbalances and promote healing, making it a powerful tool in the management of a huge range of medical conditions.

Final thoughts

So, there we have it.

A brief but hopefully informative introduction to the endocannabinoid system and how medical cannabis can interact with it to achieve therapeutic effects.

If you would like to learn more about the basics of medical cannabis, check out our entire New Patient blog series, and dive into our blog and education sections for more in-depth articles.

And, as always, make sure to consult with a specialist before making any decisions regarding your current treatment plan.

It is important to seek medical advice before starting any new treatments. The patient advisors at Releaf are available to provide expert advice and support. Alternatively, click here to book a consultation with one of our specialist doctors.

Elevate your wellness with medical cannabis

Get comprehensive care, convenience, and confidence with an all-in-one treatment plan.

Am I eligible?
Authors

Sam North, a seasoned writer with over five years' experience and expertise in medicinal cannabis, brings clarity to complex concepts, focusing on education and informed use.

Editorial Policy

All of our articles are written by medical cannabis experts, guided by strict sourcing guidelines, and reference peer-reviewed studies and credible academic research. Our expert clinical team and compliance specialists provide valuable insights to ensure accuracy when required. Learn more in our editorial policy.


Further reading

Can I vape medical cannabis with COPD?

November is National COPD Awareness Month, a time dedicated to raising awareness of Chronic Obstructive Pulmonary Disease (COPD) and the prevention and treatment of chronic lung disease. In honour of this important event, we’re taking a closer look at the relationship between medical cannabis and chronic lung disease and answering the question: “Can I vape medical cannabis if I have COPD?”

Emily Ledger

How often should I see my doctor?

Medical cannabis treatment is quite an individual process, which means there is no one-size-fits-all answer to the question of how often you should see your doctor. Each and every patient we see here at Releaf responds at least slightly differently to their treatment protocol. This is the main reason our world-class clinical team takes such a personalised approach to each patient's care and why it is essential that all patients see their doctor regularly.

Sam North