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Glossary

2-AG (2-Arachidonoylglycerol)

2-AG (2-Arachidonoylglycerol) is an endocannabinoid (a naturally occurring cannabinoid produced by the body) that interacts with the endocannabinoid system (ECS) receptors. 2-AG is one of the two main endocannabinoids, along with anandamide, and is found in elevated levels in the brain and central nervous system.

What is the difference between endocannabinoids and cannabinoids produced by Cannabis Sativa L. plants?

 

2-AG and anandamide are both endocannabinoids produced by the human body. They are classed as cannabinoids due to their ability to interact with the ECS receptors. Cannabis (and some other plants) also produce cannabinoids, such as THC and CBD, which can also interact with the ECS receptors.

These plant-based cannabinoids are not considered endocannabinoids, as they are not produced by the body. While 2-AG and anandamide primarily bind to CB1 and CB2 receptors, plant-based cannabinoids can interact with a wider range of receptors, including specific pain and serotonin pathways.

 

What role does 2-AG play in the body? 

 

2-AG has a stronger affinity to the CB2 than the CB1 receptors.

CB2 receptors are mainly found in the immune system, while CB1 receptors are predominantly located in the central nervous system. This suggests that 2-AG may play a larger role in regulating immune function and inflammation.

 

Can medical cannabis influence 2-AG activity?

 

Yes, cannabinoids like THC and CBD can interact with the same receptors that 2-AG binds to, potentially influencing its activity.

CBD is known to interact with the CB2 receptor and can increase levels of 2-AG in the body, while THC can activate both CB1 and CB2, although shows a stronger binding affinity to CB1. 

To find out if you are eligible for medical cannabis treatment in the UK, check out our fast and free medical cannabis eligibility checker.

If you would like to learn more about medical cannabis in the UK, Releaf is here to help. In addition to this medical cannabis glossary, we have an extensive blog and education hub to explore, both filled with resources that UK medical cannabis patients, prescribers, and educators have been asking for.