Tolerance
Tolerance (when discussing medical cannabis) refers to a patient's reduced response to cannabinoids over time. When a patient builds up their tolerance, they will require a higher dose to achieve the same therapeutic effects. Some patients have a naturally higher tolerance to certain cannabinoids, whereas others will slowly build up tolerance over time.
How does tolerance develop?
Tolerance develops when your body becomes accustomed to the cannabinoids, such as THC and CBD, in medical cannabis. Over time, the receptors in your endocannabinoid system may become less responsive, leading to reduced effects from the same dose. Your prescribing specialist may recommend dose adjustments or short breaks to help reduce your tolerance.
How long does it take for tolerance to develop?
The development of tolerance varies from patient to patient. Genetics, metabolism, and frequency of use all play a role in how quickly your body builds up tolerance to cannabinoids. Some patients may notice that their tolerance develops more quickly, while others may not experience any change in their response to the same dose for a longer period of time.
Can I avoid building a tolerance to medical cannabis?
To avoid building a high tolerance, your prescribing specialist may recommend rotating strains, adjusting your dose, or even taking occasional breaks. This can help maintain the effectiveness of your treatment while minimising the need for higher doses.
How long should a tolerance break be?
If your prescribing specialist recommends a tolerance break, they will typically suggest one to two weeks. This timeframe allows for the body's endocannabinoid receptors to "reset" and potentially restore their sensitivity to cannabinoids.
Not all patients have the luxury of taking a tolerance break due to their condition or symptoms. In these cases, your prescribing specialist may suggest rotating strains or adjusting your dose to help maintain the effectiveness of your treatment.
To find out if you are eligible for medical cannabis treatment in the UK, check out our fast and free medical cannabis eligibility checker.
If you would like to learn more about medical cannabis in the UK, Releaf is here to help. In addition to this medical cannabis glossary, we have an extensive blog and education hub to explore, both filled with resources that UK medical cannabis patients, prescribers, and educators have been asking for.