Medical cannabis treatments for JHS

Yes, medical cannabis has been shown to help improve the symptoms of joint hypermobility syndrome for some patients. 

Joint hypermobility syndrome is a condition where the ligaments that usually keep joints from going past their normal range of movement are stretchier than usual. This results in joints being able to overextend and even dislocate. For example, a person may stretch their wrist or put pressure on it, and their wrist may pop out of joint.

The additional and often problematic flexibility is caused by a connective tissue disorder, which makes the collagen function differently to that of a healthy person. As well as over-flexible joints, patients may be more prone to prolapses, bruising, digestive issues, and other problems involving connective tissues.

What is the difference between hEDS and joint hypermobility syndrome?

Hypermobility Ehlers-Danlos Syndrome (hEDS) is one type of EDS with many of the same symptoms as joint hypermobility syndrome. To be diagnosed with hEDS, the patient must present diagnostic symptoms of both conditions. Someone may have the thin or fragile skin common to EDS as well as stretchy ligaments, for example. 

For most forms of EDS, there is a genetic test which will confirm the condition. However, there is no genetic test for hEDS as the cause for this variant of the condition has not been found.

What symptoms does joint hypermobility syndrome cause?

The most common symptom of hypermobility syndromes is persistent, chronic pain caused by joint and muscle over-extension and resultant strains, sprains, and stiffness. Hernias are common, as are dental issues, and patients may suffer from flat feet, digestive problems, and bruising with little pressure. There is some evidence to suggest that MCAS may be concurrent with hEDS, leading to hyperinflammation. PoTS is another problem commonly experienced by hEDS patients. 

Here are the most common symptoms patients with hEDS/joint hypermobility syndrome may experience and the impact on their quality of life:

 

What treatments are currently available for joint hypermobility syndrome?

No hypermobility syndrome is curable, as yet. Treatments are largely focused on symptom management, and range from physical therapies to pain medication. 

As pain is one of the most debilitating symptoms of hypermobility syndromes, your doctor may discuss a range of options, from NSAIDs (paracetamol, ibuprofen, etc.) to low-dose naltrexone. Naltrexone is a medication commonly used to treat alcohol dependence, and may have side effects ranging from nausea and vomiting to headaches and cramps. A doctor will normally have to take a trial-and-error approach to find the right dose that balances the benefits of the medication with the potential downsides. 

Physical therapy can also be an important part of hEDS/hypermobility treatment. Gentle exercise that strengthens the muscles surrounding joints may help prevent subluxations.

If hEDS patients have PoTS, they may need beta blockers or other medications that regulate heart rate. Where MCAS symptoms are present, a doctor may prescribe antihistamines and corticosteroids, among other medications. The range of connected conditions and symptoms that present in hEDS/hypermobility syndrome is the reason why so many patients end up taking multiple medications, often for extended periods of time.

Can medical cannabis treatment help with my joint hypermobility syndrome symptoms?

Many people seek alternative treatments for joint hypermobility syndrome because the physical symptoms, particularly pain, are challenging to manage. Some people may worry about taking too many conventional medications, and the long-term effects on overall well-being. 

Medical cannabis for joint hypermobility syndrome may address several symptoms, including:

• Pain

• Sleeplessness

• Depression

• Anxiety

• Fatigue

• Digestive problems

Even small improvements in these symptoms can represent a major uplift in a person’s quality of life.

How does medical cannabis interact with POTS in hEDS/JHS patients?

No clinical evidence exists to suggest that there are significant interactions between medical cannabis and the mechanisms related to POTS. However, some patients may find that medical cannabis helps with symptoms linked to POTS, including chronic pain and migraines. 

How does medical cannabis interact with MCAS in hEDS/JHS patients?

If you’re prescribed THC for joint hypermobility syndrome or hEDS, you may find that there are additional benefits if you also suffer from mast cell activation syndrome (MCAS). Some patients find that medical cannabis can help with the persistent pain and inflammation associated with MCAS. 

How does the endocannabinoid system relate to joint hypermobility syndrome?

The endocannabinoid system (ECS) is a network of receptors in your body that impact most aspects of wellness. A deregulated ECS can lead to poor sleep, low mood, and even skin problems.

Medications that can positively impact the ECS may help manage symptoms associated with hEDS such as chronic pain, insomnia, and depression.  

What does the research say about cannabis and joint hypermobility syndrome?

Medical cannabis for joint hypermobility syndrome and hEDS could offer some patients relief from persistent pain and other symptoms that impact their quality of life. A 2025 report in ACR Rheumatology analysed 161 patients with hypermobility spectrum disorders who had been prescribed medical cannabis. While the conclusion noted the limitations of such a small study group, the results indicated that pain and anxiety levels were improved.

A 2025 review of anxiety-based medical cannabis studies found that 70% of the research indicated that the cannabinoids found in medical cannabis were linked to reduced social and general anxiety. 

There is also additional evidence to support the administering of medical cannabis for chronic pain. One 2024 article published in the journal Cureus assessed 290 patients with chronic musculoskeletal pain conditions. They self-reported a decrease on the 1-10 pain scale from an average of 6.16 to 3.89. 

What types of Releaf UK medical cannabis can be legally prescribed for joint hypermobility syndrome?

A Releaf clinician may be able to prescribe you medical cannabis in the following formats:

• THC vapes

• Oils

• Pastilles

• Dried flower for vaporisers

• Capsules

You’ll discuss which formats are best for you and your lifestyle. 

Am I eligible for UK medical cannabis treatment for joint hypermobility syndrome?

Today, there are many conditions medical cannabis can be prescribed for in the UK. These may include symptoms of joint hypermobility syndrome or EDS, including depression, anxiety, and pain, among others.  

To find out if you could be eligible, you can use Releaf’s medical cannabis eligibility checker. If you’re eligible, you can book a consultation and discover what potential relief options are available. 

Here’s how Releaf pricing works:

 

All Releaf patients are eligible for a UK medical cannabis card, completely free of charge once the first prescription is paid for. This card is delivered separately from your medication and may take 3-5 days to arrive. It’s not a guarantee that you won’t be stopped by the police, but a medical cannabis card can help you quickly identify yourself as a legal medical cannabis patient. If you’re planning an overseas getaway, Releaf can offer advice on this, including when you need travel certificates.

Releaf is the most trusted UK medical cannabis clinic, with a world-class clinical team of 50+ clinicians with expertise in a range of conditions, including hEDS. Discover if you’re eligible for medical cannabis for joint hypermobility syndrome with the medical cannabis eligibility checker, or simply contact our team.

FAQs on medical cannabis for joint hypermobility syndrome

Can medical cannabis help with subluxation pain specifically?

Taking THC/CBD for joint hypermobility syndrome may have a therapeutic effect on subluxation pain, for some patients. Medical cannabis is sometimes prescribed for pain relief for both musculoskeletal pain, caused by the shifting of muscles and bones, and neuropathic pain, which can occur when nerves are compressed by overextended joints and surrounding tissues.

Does medical cannabis interact with the medications I am already taking for hEDS/JHS?

Your Releaf clinician will carefully review your current treatment plan, including any pharmaceuticals, to check for possible interactions. Remember to mention any medications you’re taking, including over-the-counter treatments or supplements, that may not be on your medical record. 

Can medical cannabis help with hEDS brain fog?

Some people find that medical cannabis contributes to lower fatigue levels, thanks to improved sleep and lower pain levels. Reduced fatigue could aid with improved concentration and focus, helping reduce the impact of brain fog.