Medical cannabis treatments for mast cell activation syndrome (MCAS)
Mast cell activation syndrome (MCAS) is a complex condition caused by the release of chemical mediators from abnormal mast cells, leading to a range of symptoms. Medical cannabis may be prescribed to help manage some of these symptoms as part of a wider treatment plan.
As a CQC-regulated clinic, our world-class clinical team can assess whether prescribed medical cannabis could improve quality of life for MCAS patients.
65 to 70%
30-year
delay in definitive MCAS diagnosis for many patients
2 in 3
patients with Postural Tachycardia Syndrome (PoTS) and Ehlers-Danlos syndrome (EDS) also show signs of MCAS
97%
of prescribed medical cannabis patients report experiencing an improved quality of life
Symptoms
Abdominal cramps
Breathlessness or wheezing
Fatigue
Feeling faint or fainting
Headache
Irritated eyes
Itching, hives or nettle rash (urticaria)
Nausea/vomiting
Rapid pulse (tachycardia)
Red skin (flushing)
Skin swelling that moves around the body
Variable blood pressure
If you’re experiencing any of these symptoms, it’s important to seek tailored advice from a medical professional. In severe cases, MCAS may also cause anaphylaxis, which will require immediate treatment.
Treatment options:
If you have gout, there are several treatment options available to help relieve symptoms during a flare-up and prevent further potential flares. These include:
H1 antihistamines (cetirizine, loratadine, fexofenadine)
H2 antihistamines (famotidine)
Leukotriene blockers (montelukast)
Low histamine diet
Mast cell stabilisers (sodium cromoglycate, ketotifen)
Prescribed medical cannabis treatments
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Whether you’re new to cannabis-based medicines, switching from another medical cannabis clinic, or self-medicating, we’ll put you back in control of your health.
A word from our specialist
“Mast Cell Activation Syndrome (MCAS) can be a hugely unpredictable condition for patients to live with, as symptoms can flare up across multiple areas of the body with little warning. That uncertainty can have a significant impact on everyday life.
Because MCAS affects everyone differently and has highly variable symptoms, it can also be particularly difficult to diagnose, leaving many patients struggling to access the treatments they need, when they need them most.
A medical cannabis prescription may be worth looking at alongside existing conventional treatments, like antihistamines and mast cell stabilisers. While it won't be right for everyone, some patients report notable improvements in day-to-day symptom management.”

Dr Alex Van Heerden
Medical Director





















